PREDICTING DELETERIOUS MISSENSE GENETIC VARIANTS VIA INTEGRATIVE SUPERVISED NONNEGATIVE MATRIX TRI-FACTORIZATION

Predicting deleterious missense genetic variants via integrative supervised nonnegative matrix tri-factorization

Abstract Among an assortment of genetic variations, Missense are major ones which a small subset of them may led to the upset of the protein function and ultimately end in human diseases.Various machine learning methods were declared to differentiate deleterious and benign missense variants by means of a large number of features, including structur

read more


Lipoproteins, cholesterol homeostasis and cardiac health

Cholesterol is an essential substance involved in many functions, such as maintaining cell membranes, manufacturing vitamin D on surface of the skin, producing hormones, and possibly helping cell connections in the brain.When cholesterol levels rise in the blood, they can, however, have dangerous consequences.In particular, cholesterol has generate

read more

Malay folk genre pantun: traditions and modernity

The aim of the study is to analyze and systematize the features of pantun, both traditional for this Malay folklore genre and due to its historical development, and uniqueness, inherent in individual pantuns, as well as to identify the reasons for the relevance of this genre in Malay culture.Comparative-typological, descriptive-functional, and cult

read more

Visualizing Nudivirus Assembly and Egress

ABSTRACT Enveloped viruses hijack cellular membranes in order to provide the necessary material for virion assembly.In particular, viruses that replicate and assemble inside the nucleus have developed special approaches to moen voss toilet paper holder modify the nuclear landscape for their advantage.We used electron microscopy to investigate cellu

read more